Imaging α-Hemolysin with Molecular Dynamics: Ionic Conductance, Osmotic Permeability, and the Electrostatic Potential Map
نویسندگان
چکیده
منابع مشابه
Imaging alpha-hemolysin with molecular dynamics: ionic conductance, osmotic permeability, and the electrostatic potential map.
alpha-Hemolysin of Staphylococcus aureus is a self-assembling toxin that forms a water-filled transmembrane channel upon oligomerization in a lipid membrane. Apart from being one of the best-studied toxins of bacterial origin, alpha-hemolysin is the principal component in several biotechnological applications, including systems for controlled delivery of small solutes across lipid membranes, st...
متن کاملMolecular Dynamics of Membrane-Spanning DNA Channels: Conductance Mechanism, Electro-Osmotic Transport, and Mechanical Gating.
DNA self-assembly has emerged as a new paradigm for design of biomimetic membrane channels. Several experimental groups have already demonstrated assembly and insertion of DNA channels into lipid bilayer membranes; however, the structure of the channels and their conductance mechanism have remained undetermined. Here, we report the results of molecular dynamics simulations that characterized th...
متن کاملThe Effect of Aluminum, Gallium, Indium- Doping on the Zigzag (5, 0) Boron-Nitride Nanotubes: DFT, NMR, Vibrational, Thermodynamic Parameters and Electrostatic Potential Map with Electrophilicity Studies
Influence of Aluminum, Gallium, Indium- Doping on the Boron-Nitride Nanotubes (BNNTs) investigated with density functional theory (DFT) and Hartreefock (HF) methods. For this purpose, the chemical shift of difference atomic nucleus was studied using the gauge included atomic orbital (GIAO) approch. In the following, structural parameter values, electrostatic potential, thermodynamic parameters,...
متن کاملComparison of physiological and molecular responses of Melissa officinalis L. to osmotic stress imposed by drought and salinity with iso-osmotic potential in hydroponic culture
This study was performed to compare some physiological and molecular responses of lemon balm to osmotic stress imposed by drought and salinity stresses with equal osmotic potential in hydroponic culture. Growing lemon balm plants in hydroponic culture were treated with drought and salinity stress using polyethylene glycol 6000 and sodium chloride for 14 days. Then, seedlings were sampled to eva...
متن کاملThe Apparent Permeability of the Nucleus Pulposus Is Increased by Ionic Osmotic Effects
Experimental data on bovine nucleus pulpopi has been acquired that show that the apparent permeability of the tissue’s matrix depends on the ionic concentration of the permeating fluid. These results provide evidence for an ionic concentration gradient mechanism that increases the fluid flow within the tissue, thereby increasing the apparent permeability. Our analysis suggests that 50% of the f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2005
ISSN: 0006-3495
DOI: 10.1529/biophysj.104.058727